Recent Publications

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2023

Rapid profiling of DNA replication dynamics using mass spectrometry-based analysis of nascent DNA

Mohamed E. Ashour, Andrea K. Byrum, Alice Meroni, Jun Xia, Saurabh Singh, Roberto Galletto, Susan M. Rosenberg, Alessandro Vindigni, Nima Mosammaparast. Journal of Cell Biology. Apr 3;222(4):e202207121.. 

Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells

Rachel Johnston, Brendan Mathias, Stephanie J. Crowley, Haley A. Schmidt, Lynn S. White, Nima Mosammaparast, Abby M. Green, Jeffrey J. Bednarski. EMBO Reports. Jan 9;24(1):e55429.

How RNA impacts DNA repair

Ning Tsao, Mohamed E. Ashour, Nima Mosammaparast. DNA Repair. Nov; 131:103564.

RAD51 Foci as a Biomarker Predictive of Platinum Chemotherapy Response in Ovarian Cancer

Amanda J. Compadre, Lillian N. van Biljon, Mark C. Valentine, Alba Llop-Guevara, Emily Graham, Bisiayo Fashemi, Andrea Herencia-Ropero, Emilee N. Kotnik, Isaac Cooper, Shariska P. Harrington, Lindsay M. Kuroki, Carolyn K. McCourt, Andrea R. Hagemann, Premal H. Thakar, David G. Mutch, Matthew A. Powell, Lulu Sun, Nima Mosammaparast, Violetta Serra, Peinan Zhao, Elena Lomonosova, Dineo Khabele, Mary M. Mullen. Clinical Cancer Research. Jul 5;29(13):2466-2479.

The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.

Luke Buerer, Nathanial E. Clark, Anasthasia Welch, Chaorui Duan, Allison J. Taggart, Brittany A. Townley, Jing Wang, Rachel Soemedi, Stephen Long, Chien-Ling Lin, Yi Zeng, Adam Katolik, Jonathan P. Staley, Masad J. Damha, Nima Mosammaparast, William G. Fairbrother. Res. Sq. Jun 13:rs.3.rs-2931976. (Preprint) 

Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex

Junqiao Jia, Tarek Hilal, Katherine E. Bohnsack, Aleksandar Chernev, Ning Tsao, Juliane Bethmann, Aruna Arumugam, Lane Parmely, Nicole Holton, Bernhard Loll, Nima Mosammaparast, Markus T. Bohnsack, Henning Urlaub, Markus C. Wahl. Nature Communications. Apr 5;14(1):1886.

Brittany A. Townley*, Luke Beurer*, Ning Tsao*, Albino Bacolla, Fadhel Mansoori, Timur Rusanov, Nathanial Clark, Negar Goodarzi, Nicholas Schmidt, Sridhar N. Srivatsan, Hua Sun, Reilly A. Sample, Joshura R. Brickner, Drew McDonald, Miaw-Sheue Tsai, Matthew J. Walter, David F. Wozniak, Alex S. Holehouse, Vladimir Pena, John A. Tainer, William G. Fairbrother, Nima Mosammaparast. Molecular Cell. Jul 6;83(13):2258-2275.

2022

Mary M. Mullen, Elena Lomonosova, Michael D. Toboni, Alyssa Oplt, Emily Cybulla, Barbara Blachut, Peinan Zhao, Hollie Noia, Daniel Wilke, Erinn B. Rankin, Lindsay M. Kuroki, Andrea R. Hagemann, Ian S. Hagemann, Carolyn K. McCourt, Premal H. Thaker, David G. Mutch, Matthew A. Powell, Nima Mosammaparast, Alessandro Vindigni, Katherine C. Fuh. Molecular Cancer Research. Feb;20(2):265-279.

Valentina Lukinovic, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Coute, Michiel Vermeulen, Pierre Hainaut, Pawel Mazur*, Nima Mosammaparast*, Nicolas Reynoird*. Cancer Discovery. Sep 2;12(9):2158-2179.

Ning Tsao, Jennifer M. Soll, Nima Mosammaparast. STAR Protocols. Apr 1;3(2):101268.

Use of high-performance liquid chromatography-mass spectrometry (HPLC-MS) to quantify modified nucleosides

Rebecca Rodell, Ning Tsao, Adit Ganguly, Nima Mosammaparast. Methods in Molecular Biology. 2444:125-140.

Immunoaffinity purification of epitope-tagged DNA repair complexes from human cells

Brittany A. Townley, Jennifer M. Soll, Nima Mosammaparast. Methods in Molecular Biology. 2444:29-41.

Patrick M. Lombardi, Sara Haile, Timur Rusanov, Rebecca Rodell, Rita Anoh, Julia G. Baer, Kate A. Burke, Lauren N. Gray, Abigail R. Hacker, Kayla R. Kebreau, Christine K. Ngandu, Hannah A. Orland, Emmanuella Osei-Asante, Dhane P. Schmelyun, Devin E. Shorb, Shaheer H. Syed, Julianna M. Veilleux, Ananya Majumdar, Nima Mosammaparast, Cynthia Wolberger. Journal of Biological Chemistry. Feb;298(2):101545.

2021

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim. Nature Communications. 3;12(1):6321.

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim. Nature Communications. 3;12(1):6321.

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Ning Tsao, Joshua Brickner, Rebecca Rodell, Adit Ganguly, Matthew Wood, Clement Oyeniran, Tanveer Ahmad, Hua Sun, Albino Bacolla, Lisheng Zhang, Valentina Lukinovic, Jennifer M. Soll, Brittany A. Townley, Alexandre G. Casanova, John A. Tainer, Chuan He, Alessandro Vinidigni, Nicolas Reynoird, Nima Mosammaparast. Molecular Cell. Oct 21;81(20):4228-4242.

Mechanisms of damage tolerance and repair during DNA replication

Mohamed E. Ashour, Nima Mosammaparast. Nucleic Acids Research. Apr 6;49(6):3033-3047.

The complexity and regulation of repair of alkylation damage to nucleic acids
The complexity and regulation of repair of alkylation damage to nucleic acids

Ning Tsao, Orlando Scharer*, Nima Mosammaparast*. Nucleic Acids Research. Apr 6;49(6):3033-3047.

Ning Tsao, Orlando Scharer*, Nima Mosammaparast*. Nucleic Acids Research. Apr 6;49(6):3033-3047.

2020

“53BP1 imposes distinct pre- and post-resection blocks on homologous recombination.”

Callen E, Zong D, Wu W, Wong N, Stanlie A, Dumitrache LC, Byrum A, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark J, Mosammaparast N, McKinnon P, Nussenzweig A.

Mol Cell. 2020 Jan 2;77(1):26-38.e7.

Homologous recombination deficiency real-time clinical assays, ready or not?

Katherine Fuh, Mary Mullen, Barbara Blachut, Elizabeth Stover, Panagiotis Konstantinopoulos, Joyce Liu, Ursula Matulonis, Dineo Khabele, Nima Mosammaparast, Alessandro Vindigni

Gynecol Oncol. 2020 Dec;159(3):877-886.

“Barrier-to-autointegration factor 1 protects against a basal cGAS-STING response.”

Ma H, Qian W, Bambouskova M, Collins PL, Porter SI, Byrum A, Zhang R, Klimstra WB, Artyomov M, Oltz EM, Mosammaparast N, Miner JJ, Diamond MS.

mBio. 2020 Mar 10;11(2):e00136-20.

2019

Defining and Modulating 'BRCAness'

Andrea K Byrum 1, Alessandro Vindigni 2, Nima Mosammaparast 3

Trends Cell Biol. 2019 Sep;29(9):740-751.

Intersections between transcription-coupled repair and alkylation damage reversal

Joshua R Brickner 1, Brittany A Townley 1, Nima Mosammaparast 2

DNA Repair (Amst). 2019 Sep;81:102663.

XLF and H2AX function in series to promote replication fork stability
RNA Modifications: Reversal Mechanisms and Cancer
Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing

2018

WDFY4 is required for cross-presentation in response to viral and tumor antigens

Jennifer M Soll 1, Joshua R Brickner 1, Miranda C Mudge 1, Nima Mosammaparast 2

J Biol Chem .2018 Aug 31;293(35):13524-13533.

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining
RNA Modifications: Reversal Mechanisms and Cancer
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling

PubMed Publications